The biggest problem I have had has been with saddle sores. Up until today, my sitz bones were just on fire as I rode. I had to stop frequently while riding each day's route to get my butt off the saddle. I now have a regular pharmacopeia of chamois creams, diaper creams and ointments, and pain meds. I was the only person to stay in camp all day yesterday on our layover day; I gambled that a full day off my saddle would be restorative and improve my riding comfort. My gamble paid off! My ride today was not pain free, but I could ride continuously--only taking breaks to eat and sightsee.
I definitely feel like I've found my groove at this point. Good thing, too; we have some steep, long days coming up in Tennessee and Kentucky.